HGH Fragment 176-191 (Nasal Spray) – Product Details

HGH Fragment 176-191 is a synthetic peptide derived from human growth hormone (HGH). It consists of amino acids 176 to 191 of the HGH protein. This specific fragment is believed to retain some of the lipolytic (fat-reducing) properties of the full-length HGH molecule. It has been studied for its potential to promote fat loss and aid in weight management. Researchers have investigated its effects in various contexts, but it’s important to emphasize that these studies are typically conducted for scientific research purposes, and not for any medical or therapeutic applications.

• CAS Number: 97305-48-1
• Molar Mass: 848.9 g/mol-1
• Chemical Formula: C39H60N8O13
• IUPAC Name: (2S)-6-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid
• Synonym: HGH Fragment 176-191 (also known as the Growth Hormone Fragment 176-191)

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What is HGH Fragment 176-191?

HGH 176-191, a synthetic analog of human growth hormone, consists of a peptide chain comprising 16 amino acids. It is often colloquially termed the “lipolytic fragment” of HGH, based on research indicating its potential to induce fat loss in animal models [R].

Animal studies have suggested that HGH 176-191 holds promise as an anti-obesity agent. Furthermore, a cell-based investigation has revealed that this modified HGH variant enhances the anti-cancer effectiveness of compounds designed to target breast cancer cells [R].

How Does HGH Fragment 176-191 Work?

HGH Fragment 176-191 operates by targeting specific mechanisms. It primarily influences the regulation of fat metabolism and fat breakdown. Here’s a simplified explanation of the proposed mechanism of action:

Lipolysis Stimulation

HGH Fragment 176-191 is believed to stimulate lipolysis, which is the breakdown of fats into fatty acids and glycerol. This process encourages the release of stored body fat, making it available for energy consumption.

Selective Action

This fragment primarily affects fat cells and does not significantly impact other cellular activities. It is designed to be selective in promoting fat loss while avoiding broader systemic effects typically associated with full-length human growth hormone (HGH).

Weight Management

By enhancing the mobilization and utilization of fat for energy, HGH Fragment 176-191 may support weight management and fat loss efforts in subjects.

It’s crucial to emphasize that the use of HGH Fragment 176-191 in research is for scientific purposes and should not be associated with human consumption or medical applications.

HGH Fragment 176-191 Research

Numerous animal and cell-based investigations have been undertaken to explore the properties of HGH Fragment 176-191. Findings from these studies indicate that this synthetic peptide exhibits the potential to trigger lipolysis, inhibit lipogenesis, and augment the cytotoxicity of compounds targeting cancer cells in breast cancer lines.

In mice, HGH Fragment 176-191 has exhibited a transient increase in blood glucose levels, followed by a more prolonged elevation in plasma insulin levels. Furthermore, this research compound has displayed promise in terms of weight management and fat reduction effects.

HGH 176-191 and Fat Reduction

An animal investigation unveiled compelling findings, demonstrating that a 14-day regimen of HGH Fragment 176-191 brought about a decrease in body weight and body fat among obese mice. The researchers observed that this synthetic peptide facilitated fat loss by elevating energy expenditure and encouraging the oxidation of fat reserves [R].

HGH 176-191 and Combatting Obesity

Animal research highlighted a noteworthy discovery, as daily oral doses of HGH 176-191 effectively curtailed over 50% of the weight gain in the subjects when compared to the control group. This outcome underscores the potential of this synthetic peptide as a safe therapeutic candidate for obesity management [R].

Additionally, in another mouse study, chronic treatment with HGH or its HGH 176-191 counterpart increased the oxidation of fat cells in obese individuals and contributed to weight loss. It’s worth noting that, unlike full-length HGH, this specific fragment did not induce hyperglycemia, reduce insulin secretion, or compete for HGH receptors [R].

HGH 176-191 and its Impact on Breast Cancer

A cell-based investigation unveiled a noteworthy finding, indicating that HGH Fragment 176-191 amplified the cytotoxic effectiveness of compounds designed to target breast cancer cells. In particular, chitosan nanoparticles loaded with HGH 176-191 displayed potential for enhanced cytotoxicity against breast cancer cells, offering promise in the field of anti-cancer research [R].

Moreover, the incorporation of HGH 176-191 in nanoparticles may facilitate their accumulation in tumor tissues while minimizing exposure to non-targeted tissues. This holds the potential to enhance the therapeutic efficacy and mitigate adverse effects associated with this anti-cancer compound.

HGH 176-191 and Osteoarthritis Management

A study conducted in 2016 shed light on the potential benefits of hyaluronic acid loaded with HGH 176-191 in a rabbit model of osteoarthritis. Results demonstrated that this combination was more effective than either hyaluronic acid or HGH Fragment 176-191 alone. Furthermore, intra-articular administration of HGH Fragment 176-191 was found to enhance cartilage regeneration. It was also observed that osteoarthritic rabbits receiving HGH 176-191 injections exhibited reduced morphological and histopathological damage compared to the control group [R].

Summary

HGH Fragment 176-191, a synthetic peptide, has shown promise in various research studies. It demonstrated the potential to reduce body weight and fat in obese animals by increasing energy expenditure and fat oxidation. Moreover, it enhanced lipolytic activity without adversely affecting insulin sensitivity. In obesity studies, it significantly curtailed weight gain without inducing hyperglycemia. HGH Fragment 176-191 also exhibited potential in enhancing the cytotoxicity of compounds targeting breast cancer cells. Additionally, in osteoarthritis research, its combination with hyaluronic acid proved more effective in promoting cartilage regeneration and reducing damage, offering therapeutic potential in various contexts.

Where to Buy HGH Fragment 176-191 for Sale?

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